Is It Bad to Take Aspirin on my PRP Treatment?


We've all been told for many years that we need to take an aspirin a day to help prevent heart attacks. Hence, there are many people that take this drug every day. However, given that aspirin is a blood thinner, does it impact the way your platelets work? If so, does that change the way platelet-rich plasma works?

What Is PRP?

Platelet-rich plasma (PRP) is a cocktail made from concentrating the platelets in your blood. The procedure is commonly used these days in diseases like knee arthritis, tendon tears, and other orthopedic problems. However, like anything made from your body, what you take as far as daily medications may impact the efficacy of the PRP made from your blood.

Aspirin Found to Inhibit Growth Factor Release in PRP Treatment

Before we look at the study, it's important to understand that in a platelet-rich plasma (PRP) treatment, growth factors are the good stuff that is slowly released from the platelets after an injection. These growth factors stimulate the local stem cells to wake up and get to work at repairing and healing tissues. There are many types of growth factors released, including VEGF, PDGF, TGF-B, and more.

The new study, consisting of 12 men, investigated the effects of aspirin on the release of growth factors from the platelet in PRP. Blood was drawn and PRP prepared prior to aspirin initiation and grouped by nonactivated or activated (AA and TBN) PRP, and the process was repeated after the men had been on 81 mg of aspirin for two weeks. Blood and PRP comparisons were then made on the before and after collections. The results? The release of growth factors (specifically VEGF, PDGF-AB, and TGF-β1) was reduced in the AA-activated PRP after these subjects had taken the low-dose of aspirin for two weeks. While the study discussed that there was a way to possibly fix some of these issues, not all of them could be fixed.

What does this mean exactly to those who are taking aspirin and planning a platelet-rich plasma (PRP) treatment? It means your aspirin use could sabotage your PRP treatment, making your outcomes less desirable than they could be.

How Long Do the Effects of Aspirin Last?

When should you stop aspirin prior to a stem cell procedure? It takes about 10 days for the effects of aspirin on platelets to wear off. Hence, to be safe, I would stop the aspirin for two weeks before the procedure, and given that platelets have to release growth factors for two weeks, you should be off it for two weeks after the procedure as well. Obviously, discuss all of this with your doctor!

The upshot? You should likely get off aspirin before and after your PRP procedure. Just follow the guidelines above after clearing it with your doctor.